Phagocytosis of Mycobacterium leprae down-regulates anti-microbial activity of murine macrophages against Mycobacterium intracellulare
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چکیده
منابع مشابه
Adjuvant activity of Mycobacterium leprae.
Mycobacterium leprae organisms isolated from infected spleen and liver tissue by zonal centrifugation were shown to possess adjuvant activity. Histochemical examination of the footpad macrophage epithelioid granuloma showed that macrophages contained large amounts of hemosiderin after the injection of M. leprae and much smaller amounts after the injection of M. tuberculosis.
متن کاملMetabolism of Mycobacterium leprae in macrophages.
The incorporation of 14C-labeled palmitic acid ( [U-14C]PA) into the phenolic glycolipid-I (PGL-I) fraction of Mycobacterium leprae was studied in a murine macrophage system in vitro. Peritoneal macrophages from Swiss Webster mice were infected with fresh viable or Formalin-killed M. leprae harvested from infected footpads of nu/nu mice, and [U-14C]PA was added to the culture medium. Labeled gl...
متن کاملActivity of derivatives and analogs of dapsone against Mycobacterium leprae.
Of 25 dapsone derivatives and analogs screened for activity against Mycobacterium leprae in the mouse footpad system, only 7 were active. All seven were metabolized to or contaminated with dapsone.
متن کاملActivity of ofloxacin and pefloxacin against Mycobacterium leprae in mice.
The fluorinated quinolones are potent antibacterial compounds active against both gram-negative and gram-positive bacteria (1, 3-5, 11-13). Some are also active against mycobacteria in general (3, 9, 10, 13) and Mycobacterium tuberculosis in particular (1; unpublished observations). In view of the limited number of drugs active against Mycobacterium leprae, it was of interest to test some of th...
متن کاملEnhanced intramacrophage activity of resorcinomycin A against Mycobacterium avium-Mycobacterium intracellulare complex after liposome encapsulation.
The activities of free and liposomal resorcinomycin A against Mycobacterium avium-Mycobacterium intracellulare complex (MAC) grown in broth and in murine peritoneal macrophages were evaluated. Liposomal resorcinomycin A was composed of dimyristoyl phosphatidylcholine and phosphatidylinositol at a molar ratio of 9:1. Both free resorcinomycin A and liposomal resorcinomycin A showed no toxicity to...
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ژورنال
عنوان ژورنال: JAPANESE JOURNAL OF LEPROSY
سال: 2012
ISSN: 1342-3681,1884-314X
DOI: 10.5025/hansen.81.175